Milk and Dairy Products

Title Effects of Processing Conditions During Manufacture on Retronasal-Aroma Compounds from a Milk Coffee Drink
Author M.Ikeda, M.Akiyama, Y.Hirano, K.Miyazi, M.Kono*1, Y.Imayoshi*1, H.Iwabuchi*1, T.Onodera*2, and K.Toko*2
*1 San-Ei Gen F.F.I., Inc., *2Kyushu Univ.
Journal Journal of Food Science 83(3): 605-616 (2018)
Summary Regarding the manufacture of a ready-to-drink (RTD) milk coffee that retained original volatile characteristics, an investigation of retronasal-aroma compounds from an RTD milk coffee revealed that a new process without pH adjustment of coffee was superior to a conventional process with the pH adjustment.


Title Potential Role of Amino Acid/Protein Nutrition and Exercise in Serum Albumin Redox State
Author Y.Wada, Y.Takeda, and M.Kuwahata*
*Departments of Nutrition Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
Journal Nutrients, 10(1), Art.17 (2018)
Summary This article extensively reviews serum albumin and the redox state of albumin in the context of amino acid/protein nutritional status and exercise training.

Bifidobacteria and Intestinal Flora

Title Degradation of food-derived opioid peptides by Bifidobacteria
Author T.Sakurai, A.Yamada, N.Hashikura, T.Odamaki, JZ.Xiao
Journal Beneficial Microbes 9(4): 675-682 (2018)
Summary We found that, some B. longum subsp. infantis and B. bifidum strains had a degradative activity in food-derived opioid peptides, which have been reported to cause diseases, such as gastrointestinal inflammation, celiac disease, and mental disorders.
Title Effects of Bifidobacterium breve B-3 on body fat reductions in pre-obese adults: A randomized, double-blind, placebo-controlled trial
Author J.Minami, N.Iwabuchi, M.Tanaka, K.Yamauchi, J.Xiao, F.Abe, and N.Sakane* *National Hospital Organization Kyoto Medical Center
Journal Bioscience of Microbiota, Food and Health 37(3): 67-75(2018)
Summary The effects of the consumption of Bifidobacterium breve B-3 on body fat reduction in healthy pre-obese (25 ≤ BMI < 30) adults were investigated in a double-blind, placebo-controlled trial. Body fat mass was significantly lower in the B-3 group than in the placebo group. Waist circumference in the B-3 group was significantly lower at week 12 than at the baseline.
Title Genomic diversity and distribution of Bifidobacterium longum subsp. longum across the human lifespan
Author T.Odamaki, F.Bottacini*, K.Kato, E.Mitsuyama, K.Yoshida, A.Horigome, JZ.Xiao, and D.van Sinderen*
*APC Microbiome Institute and School of Microbiology, National University of Ireland
Journal Scientific Reports 8(1): Art. 85 (2018)
Summary We performed a comparative genome analysis of Bifidobacterium longum subsp. longum to unravel the reason why this subspecies are widely distributed across all generation. As results, a broad distribution of them across the human lifespan is due to a high transfer level between family members. We furthermore identified a variety of genes which could enhance their adaptation and increase competitiveness in the gut environment, enriched in genomes corresponding to specific ages.
Title Therapeutic potential of Bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer's disease
Author Y.Kobayashi, H.Sugahara, K.Shimada*1, E.Mitsuyama, T.Kuhara, A.Yasuoka*1, T.Kondo*1, K.Abe*1,2 and JZ.Xiao
*1Group for Food Functionality Assessment, Kanagawa Institute of Industrial Science and Technology, *2Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Journal Scientific Reports 7(1):13510 (2017)
Summary We focused on gut-microbiota-brain axis and found that oral administration of Bifidobacterium breve A1 to Alzheimer's disease model mice improved cognitive dysfunction through suppressing the expression of inflammation and immune-reactive genes.

Functional Ingredients

Title Investigation of potent odorants generated during the production
Author H.Nakada, M.Ohata*1,2, M.Hosaka*1, H.Ochi, F.Abe, and K.Arihara*1
*1Kitasato University, *2Nihon University
Journal Animal Science Journal 89(9):1348-1354(2018)
Summary We evaluated predominant odorants of Whey protein hydrolysates(WPH), and our results showed that difference of odor characteristics between whey protein concentrate(WPC) and WPH, and three odor-active compounds contributed to the odor of WPH. Additionally, this study suggests that specific free amino acids are important precursors for generation of these compounds in manufacturing process of WPH.
Title Antihypertensive effect of the casein-derived peptide Met-Lys-Pro in individuals with high-normal blood pressure or grade 1 hypertension-A randomized, double-blind, placebo-controlled, parallel-group trial-
Author N.Yuda, M.Tanaka, A.Yamada, D.Ochi, K.Yamauchi, F.Abe, and N.Sakane*
*National Hospital Organization Kyoto Medical Center
Journal Japan Pharmacology & Therapeutics 46(4):529-37(2018)
Summary Antihypertensive effect of the casein-derived peptide Met-Lys-Pro (MKP) was confirmed by clinical trial. Daily MKP ingestion is a effective systolic blood pressure lowering treatment for people with mildly high blood pressure.
Title Phytosterols derived from Aloe Vera (Aloe sterol) supplementation prevents skin photoaging acceration by estrogen deficiency.
Author M.Saito, Z.Yao, M.Tanaka, E.Misawa, K.Yamauchi, and F.Abe
Journal FRAGRANCE JOURNAL 45(12): 29-36 (2017)
Summary We have showed that Aloe sterol improving skin dryness in a clinical trial and the anti-photoaging effect in estrogen deficiency model. This review described these results and the usefulness of Aloe sterol supplementation for skin beauty.
Title Blood pressure-lowering effects of casein-derived peptide met-lys-pro in subjects with high-normal blood pressure and grade 1 hypertension - A randomized, double-blind, placebo-controlled, parallel-group, trial-
Author D.Ochi, A.Yamada, K.Yamauchi, F.Abe, and Y.Tho*
*Aiwa Clinic, Latvia
Journal Japanese pharmacology & therapeutics 45(10): 1637-1648 (2017)
Summary We evaluated the effect of Met-Lys-Pro(MKP) in lowering blood pressure in subjects with high-normal blood pressure and grade 1 hypertension in a randomized, double-blind, placebo-controlled, parallel-group trial for 12 weeks.
The result showed that 100 μg MKP has a beneficial effect on lowering systolic and diastolic blood pressure.
Title Effects of lactoferrin and lactoperoxidase-containing food on the oral microbiota of older individuals
Author M.Nakano, H.Wakabayashi, H.Sugahara, T.Odamaki, K.Yamauchi, F.Abe, JZ.Xiao, K.Murakami*, K.Ishikawa*, and S.Hironaka*
*Department of Special Needs Dentistry, Division of Hygiene and Oral Health, Showa University School of Dentistry
Journal Microbiology and Immunology 61(10): 416-426 (2017)
Summary The long-term ingestion of lactoferrin and lactoperoxidase-containing tablets promotes a shift from a gram-negative-dominated unhealthy community to a gram-positive-dominated healthy community in the oral microbiota.